As I age, my vision is getting worse (and it's already pretty bad). At work, I use a three monitor setup: my laptop is the middle screen, and two external monitors sit to either side. Given the large screen real estate, and given my increasingly bad eyesight, I've been having a tough time finding my mouse pointer. Windows has an option to show the location of the mouse pointer when you press the Ctrl key, but that has limited usefulness (though I do use it from time to time).
I recently stumbled upon a neat feature in Windows 10 that has helped me tremendously. There are several mouse-specific features in the Ease of Access section of the Windows settings. The pointer size can be adjusted (which is helpful to a degree), but the most helpful feature is the Pointer Color setting. There's an option to adjust the pointer color based on whatever color is beneath it. It took a little getting used to, but I can now find the mouse pointer a lot easier than I could before.